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Fatigue and Headaches Fatigue can occur as the body adjusts to a lower caloric intake and changes in blood sugar regulation

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When this happens, your body produces less luteinizing and follicle-stimulating hormones, which can lead to anovulation (no egg is released) and skipped periods

Similarly, the comparison between tesofensine and semaglutide is relevant because tesofensine is a monoamine reuptake inhibitor that operates through stimulant-adjacent mechanisms that semaglutide does not share