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Novo Nordisk's research showed that higher doses of GLP-1 could correct diabetes in mice and cause weight loss, and it eventually became clear that GLP-1 receptors in the brain were suppressing the desire to eat

Diabetes, Obesity and Metabolism , 25(1), 1835

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For Novo Nordisks Wegovy pill, study participants achieved an average weight loss of 13.6 percent by 16 months