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In patients with T2DM, cognitive deficits are classified into three broad stages according to severity: diabetes-related cognitive decline, mild cognitive impairment (MCI) and dementia ( Oxidative stress and mitochondrial dysfunction Oxidative stress is a serious imbalance between the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and antioxidant defenses ( 2+ levels, which may have deleterious consequences

However, both the lamina propria and ASM of small bronchi exhibited lower immunoreactivity compared to the positive control, which consisted of pancreatic tissues (Figure 5B)

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