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Jan 2015;22(1):104-108

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In addition to proinflammatory cytokine production, the NLRP3 inflammasome also activates the cleavage of gasdermin D, triggering an inflammatory form of cell death called pyroptosis [34]

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All weight loss medications have undergone clinical trial testing before receiving approval and must show efficacy by demonstrating that participants taking the medication experience at least a 5% weight loss