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Conversely, in patients with anorexia nervosa, even supra-physiologic GH doses (mean maximum daily dose: 1.4 mg/day) may not be sufficient to normalize IGF-I levels (61) indicating the important role of hepatic GH sensitivity in successful IGF-I generation

This is the side effect people are talking about, even though its not front-and-center in the clinical literature

In practice, pharmaceutical firms are investing a lot, not only for new therapies but for next-gen approaches, along with refined formulations and even wider use across different patient groups

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For instance, in one observational study, a larger reduction in added sugars and a greater increase in dietary protein were seen among participants receiving GLP-1s plus dietary counseling compared to GLP-1s alone