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Histological analysis on day 7 revealed a significant decrease in the expression of proinflammatory cytokines in the wound, including TNF- and IL-6 in the D-CuP groups, accompanied by an increase in IL-10 expression (Fig

Studies demonstrate that PGC-1 overexpression activates the NRF2/HO-1 signaling pathway, thereby enhancing mitochondrial antioxidant capacity to prevent spinal motor neuron loss

Weight-based dosing provides a more individualized approach than flat-dose recommendations

Innovative approaches include: Combination Therapies : Studies are aimed to reveal the potential of combining stem cell therapy with other treatments, like collagenase injections, to improve treatment results