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For the dietary intervention studies (Table 2, n = 6 publications representing 5 independent trials), data extraction included study design and quality indicators, sample characteristics and diagnostic criteria, details of the intervention such as diet type, duration, and adherence monitoring, outcome measures including opioid peptide levels and behavioral assessments, and reported results along with effect sizes

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Evolution of the insulin-like growth factor binding protein (IGFBP) family

The best option depends on individual symptoms, tolerance, and treatment goals