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Due to the pharmacokinetics and tight regulation of plasma vitamin C, supplementation with vitamin C will have variable effects in vitamin C-replete (plasma concentrations near saturation) versus sub-optimal (plasma concentrations 1 g/day) vitamin C to prevent the common cold (211)

Therefore, it is possible that the relative activity of tirzepatide at the GLP-1R and GIPR may vary in subjects with and without diabetes as well as with the degree of hyperglycemia

References Abdalrahman SS, Smail HO, Shallal AF