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How Do GLP-1s Work in the Human Body

Retatrutide Side Effects Are Similar to Existing Diabetes and Obesity Injectables The most common side effects for retatrutide were: Nausea (16 to 27 percent of participants, depending on dosage, compared with 3.7 percent of those taking a placebo) Diarrhea (19 to 23 percent, compared with 5 percent taking a placebo) Vomiting (16 to 18 percent, compared with 2 percent taking a placebo) Nerve issues (2 to 4 percent, compared with none taking a placebo) Between 2 and 5 percent of participants on retatrutide stopped taking it before the trial ended, with a greater risk of stopping among those who took the highest dose

How side effects often change over time For some individuals, side effects may improve over time as the body adjusts to treatment

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People living with obesity face a variety of unwanted health risks, such as hypertension, heart disease, and type 2 diabetes