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[9] Slower titration may be considered for patients with significant gastrointestinal sensitivity or active inflammatory bowel disease

It also activates lysyl oxidase (LOX), the copper-dependent enzyme responsible for collagen and elastin crosslinking in the extracellular matrix

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Increased cholesterol release into bile can disrupt balance and promote gallstone formation

Since GSH is exported rapidly from liver cells and much of the export is broken down into the constituent amino acids that are then reimported into liver cells, it was necessary to include the blood compartment in our model