References Monnier M, Dudler L, Gchter R, Maier PF, Tobler HJ, Schoenenberger GA
A key randomized, double-blind, placebo-controlled crossover trial revealed that NR supplementation (1000 mg daily) for 6 weeks increased blood cellular NAD+ concentrations by approximately 60% compared to placebo [4]
Whereas substitution of Ser 18 for Ala did not affect receptor binding and activation, replacement with a charged amino acid Lys resulted in a 4-fold decrease in binding affinity
Brand-Name Pricing (2026) Mounjaro (Diabetes Indication): List price: $1,069/month ($12,828/year) Without insurance: Pay full price With insurance: $25-$300/month copay (if covered) Availability: On shortage list periodically Zepbound (Weight Loss Indication): List price: $1,069/month ($12,828/year) Without insurance: Pay full price With insurance: $25-$300/month copay (if covered) Availability: Limited, shortage issues Manufacturer Savings Cards: Eli Lilly offers savings card Reduces cost to $25-$50/month Requirements: Commercial insurance (not Medicare/Medicaid) Exclusions: Cash-pay patients ineligible Income limits: May apply For uninsured or underinsured patients, brand-name is unaffordable at $1,069/month
www.crpub.org Italian 08
