In pregnant mice given 6, 68, 460, or 760 mcg/kg/day exenatide during fetal organogenesis, skeletal variations associated with slowed fetal growth, including changes in number of rib pairs or vertebral ossifications sites, and wavy ribs were observed at 760 mcg/kg/day, a dose that produced maternal toxicity and yielded systemic exposure 390-times the human exposure resulting from the MRHD of BYETTA based on AUC comparison
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BartoliniDStabileAMBastianelliSGiustariniDPierucciSBustiCet alSARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione
This constrained hormonal response minimizes cross-axis variability, supporting clearer mechanistic evaluation of growth hormonemediated metabolic and tissue-repair endpoints
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