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Stepwise escalation: Patients will likely start at low introductory doses (24 mg) and gradually increase over several weeks to reduce GI side effects

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Recommended starting dose: Discontinue other basal insulin and/or GLP-1 agonist before initiating Xultophy Patients nave to basal insulin or a GLP-1 agonist: starting dose is 10 units once daily Patients currently on basal insulin or a GLP-1 agonist: starting dose is 16 units once daily Maintenance: titrate dose up or down by 2 units once or twice weekly, depending on blood sugar goals Missed doses: resume dosing at the next scheduled dose

Hunger may slowly reduce, and people may feel satisfied with smaller meals

Synthetic peptide with triple receptor agonist activity, C18 fatty acid modification for extended half-life